Sharon E. Bickel
Associate Professor of Biological SciencesMolecular and Cellular Biology Graduate Program
Chromosome segregation errors in human oocytes are the leading cause of miscarriages and birth defects and their frequency increases dramatically as women age. Work in my laboratory is focused on defining the pathway of events necessary for chromosomes to ""do the right thing"" during meiosis and understanding the molecular events that cause reduced fidelity of meiotic chromosome segregation as oocytes age.
Perkins, A.T., Das, T.M., Panzera, L.C. and Bickel, S.E. (2016) Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors. PNAS. doi: 10.1073/pnas.1612047113.
Giauque, C.C. and Bickel, SE. (2016) Heterochromatin-Associated Proteins HP1a and Piwi Collaborate to Maintain the Association of Achiasmate Homologs in Drosophila Oocytes. Genetics. May;203(1):173-89. doi: 10.1534/genetics.115.186460.
Weng, K.A., Jeffreys, C.A. and Bickel, S.E. (2014). Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation. PLoS Genet. Sep 11;10(9):
Subramanian, V.V. and Bickel, S.E. (2009) Heterochromatin-mediated association of achiasmate homologues declines with age when cohesion is compromised. Genetics 181:1207-1218.
Subramanian, V.V. and Bickel, S.E. (2008) Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit Smc1 is reduced. PLoS Genet. Nov;4(11):e1000263. doi: 10.1371/journal.pgen.1000263.
Page, S.L., Khetani, R.S.,Lake, C.M., Nielsen, R.J., Jeffress J.K., Bickel, S.E., and Hawley, R.S. (2008) corona is required for higher-order assembly of transverse filaments into full-length synaptonemal complex in Drosophila oocytes . PLoS Genet 4(9): e1000194. doi: 10.1371/journal.pgen.1000194.
Gause, M., Webber, H., Misulovin, Z., Haller, G., Rollins, R.A., Eissenberg, J.C., Bickel, S.E. and Dorsett, D. (2008) Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells. Chromosoma 17:51-66
Khetani, R. and Bickel, S.E. (2007) Regulation of cohesion and chromosome core morphogenesis during pachytene in Drosophila oocytes. Journal of Cell Science 120: 3123-3137.
Bickel, S E, “Aging (Not So) Gracefully,” Nature Genetics , 37 (2005) 1303-1304.
Webber, H., Howard, L. and Bickel S.E. (2004) The cohesion protein ORD is required for homolog bias during meiotic recombination. Journal of Cell Biology: 164:819-829.
Balicky, E.M., Young, L., Orr-Weaver, T.L. and Bickel, S.E. (2004) A proposed role for the Polycomb Group protein dRING in meiotic sister-chromatid cohesion. Chromosoma: 112:231-239.
Jeffreys, C.A, Burrage, P.S, and Bickel, S.E. (2003) A model system for increased meiotic nondisjunction in older oocytes. Current Biology 13:498-503.
Balicky, E.M., Endres, M.W. Lai, C, and Bickel, S.E. (2002) Meiotic cohesion requires accumulation of ORD on chromosomes prior to condensation. Mol. Biol. Cell 21:3890-3900.
Bickel, S.E., Orr-Weaver, T.L. and Balicky, E.M. (2002) The sister-chromatid cohesion protein ORD is required for chiasma maintenance in Drosophila oocytes. Current Biology 12:925-929.