C. Robertson McClung
Professor of Biological SciencesThe Patricia F. and William B. Hale 1944 Professor in the Arts and Sciences
The ability of an organism to measure time is the product of a cellular biological clock. Many phenomena controlled by the biological clock cycle on a daily basis and are called circadian rhythms. My goal is to understand the genetic and biochemical mechanisms by which an organism measures time and uses that temporal information to regulate gene expressionand cellular physiology.
Rosas, U., Mei, Y., Xie, Q., Banta, J., Zhou, R.W., Seufferheld, G., Gerard-Martinez, S., Chou, L., Bhambhra, N., Flowers, J., McClung, C.R., Hanzawa, Y., Purugganan, M.D. 2014. Variation in Arabidopsis flowering time associated with cis-regulatory variation in CONSTANS. Nature Communications: 5:3561.
McClung, C.R. 2014. Wheels within wheels: new transcriptional feedback loops in the Arabidopsis circadian clock. F1000Prime Reports 6:2
Hong, S., S.A Kim, M.L. Guerinot, & C.R. McClung. 2013. Reciprocal interaction of the circadian clock with the Fe homeostasis network in Arabidopsis thaliana. Plant Physiology 161:893-903.
McClung, C.R. 2013. Beyond Arabidopsis: The circadian clock in non-model plant species. Seminars in Cell and Developmental Biology 24:430-436.
Zhang, C., Q. Xie, R.G. Anderson, G. Ng, N.C. Seitz, T. Peterson, C.R. McClung, J.M. McDowell, D. Kong, J.M. Kwak, & H. Lu. 2013. Crosstalk between the circadian clock and innate immunity in Arabidopsis. PLoS Pathogens 9: e1003370.
Lou, P., J. Wu, F. Cheng, L.G. Cressman, X. Wang & C.R. McClung. 2012. Preferential retention of circadian clock genes during diploidization following whole genome triplication in Brassica rapa. Plant Cell 24:2415-2426.
Wang, X., F. Wu, Q. Xie, H. Wang, Y. Wang, Y. Yue, O. Gahura, S. Ma, L. Liu, Y. Cao, Y. Jiao, F. Puta, C.R. McClung, X. Xu & L. Ma. 2012. SKIP is a component of the spliceosome linking alternative splicing and the circadian clock in Arabidopsis. Plant Cell 24:3278-3295.
Lou, P., Q. Xie, X. Xu, C.E. Edwards, M.T. Brock, C. Weinig & C.R. McClung. 2011. Genetic architecture of the circadian clock and flowering time in Brassica rapa. Theoretical and Applied Genetics 123: 397-409.
Hong, S., H.-R. Song, K. Lutz, R.A. Kerstetter, T.P. Michael & C.R. McClung. 2010. Type II Protein Arginine Methyltransferase PRMT5 is required for circadian period determination in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America 107: 21211-21216.
Salomé, P.A., D. Weigel & C.R. McClung. 2010. The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and PRR9 in temperature compensation. Plant Cell 22: 3650-3661.