Elizabeth F. Smith

Dean of the Faculty of Arts and Sciences
Paul M. Dauten Junior Professor of Biological Sciences
Molecular and Cellular Biology Graduate Program Faculty Member

The proper assembly and regulated function of eukaryotic cilia is critical for development and sustained human health. We use a variety of biochemical, molecular, and genetic techniques to elucidate the signal transduction pathways that regulate motor proteins responsible for ciliary beating.

646-1129
226 Life Sciences Center
HB 6044
Department:
Biological Sciences
Administration:
Dean of Faculty
Education:
B.A. Agnes Scott College
Ph.D. Emory University

Related Links

Selected Publications

Dymek EE, and Smith EF. RSP11 serves as a RS1 adaptor and plays a fundamental role in controlling ciliary motility. (in preparation)

Dymek EE, and Smith EF. The dynamic localization of katanin during assembly of the ciliary central tubules.  (in preparation)

Loreng, TD. and EF Smith. (2017) The central apparatus of cilia and eukaryotic flagella. In Cilia and Flagella. Wallace Marshall ed. Cold Spring Harbor Laboratory Press. 9(2)

Mizuno, K., E.E. Dymek and Smith EF. (2016) Microtubule binding protein PACRG plays a role in regulating specific ciliary dyneins during microtubule sliding. (in press) Cytoskeleton. 73(12):703-711.

Perrone, C.A., D. Tritschler, R. Bower, E. T. O'Toole, M. J. Wargo, E. F. Smith, and M. E. Porter. BOP2 encodes a novel WD-repeat protein that regulates inner arm dynein activity. (in preparation)

Vasudevan, K.K., K. Song, L.M. Alford, W.S. Sale, E.E. Dymek, E.F Smith, T. Hennessey, E. Joachimiak, P. Urbanska, D. Wloga, W. Dentler, D. Nicastro, and J. Gaertig. (2015) FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein cMolecular Biology of the Cell. Feb 15;26(4):696-710.

Wren, K.N., J.M. Craft, D. Tritschler, A. Schauer, D.K. Patel, E.F Smith, M.E. Porter, P. Kner, K.F.Lechtreck. (2013) A differential cargo-loading model of ciliary length regulation by IFTCurrent Biology. Dec 16;23(24):2463-71.

DiPetrillo, C. and E.F. Smith. (2013) Methods for analysis of calcium / calmodulin signaling in cilia and flagellaMethods in Enzymology, 524: 37-57.

Dymek, E.E., T. Heuser, J. Lin, E.F. Smith, and D. Nicastro. (2012) The CSC connects three major axonemal complexes involved in dynein regulation. Molecular Biology of the Cell 23(16):3143-55

DiPetrillo, C. and E.F. Smith. (2011) The Pcdp1 complex coordinates the activity of dynein isoforms to produce wild-type ciliary motility. Molecular Biology of the Cell 22(23):4527-38 .

Brown J.M., C. DiPetrillo , E.F. Smith, G.B. Witman. (2012) A FAP46 mutant provides new insights into the function and assembly of the C1d complex of the ciliary central apparatusJournal of Cell Science 125(16):3904-13

Dymek, E.E. and E.F. Smith. (2012) PF19 encodes the p60 catalytic subunit of katanin and is required for assembly of the flagellar central apparatus in Chlamydomonas. J. Cell Science 125(Pt 14):3357-66

Goduti, D., and E.F. Smith. (2012) Analyses of functional domains within the PF6 protein of the central apparatus reveal a role for PF6 sub-complex members in regulating flagellar beat frequency. Cytoskeleton 69(3):179-94

 

DiPetrillo, C. and E.F. Smith. (2011) The Pcdp1 complex coordinates the activity of dynein isoforms to produce wild-type ciliary motility. Molecular Biology of the Cell 22(23):4527-38

Dymek, E.E., T. Heuser, D. Nicastro and E.F. Smith. (2011) The CSC is required for complete radial spoke assembly and wild-type ciliary motility. Molecular Biology of the Cell 22(14):2520-31

Smith, E.F. and R. Rohatgi. (2011) Cilia 2010: The surprise organelle of the decade. Science Signaling. 4:55 mr1. 

Straschil, U., A. Talman, D. Ferguson, K. Bunting, Z. Xu, Liz Bailes, J. Coates, T. Holder, E.F. Smith, and R. Tewari. (2010) The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes. PLoS ONE . Vol. 5:10 e12901

DiPetrillo, C., and E.F. Smith. (2010) Pcdp1 is a central apparatus protein that binds Ca 2+ -calmodulin and regulates ciliary motility. Journal of Cell Biology 189(3):601-612

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Works in Progress

"Regulation of Ciliary and Flagellar Motility: Understanding the Function of Calmodulin and Interacting Proteins”