Mary Lou Guerinot

Professor of Biological Sciences
Ronald and Deborah Harris Professorship in the Sciences
Professor in the Molecular and Cellular Biology Graduate Program

I study the molecular mechanisms of metal ion uptake and its regulation in prokaryotic and eukaryotic cells using a combined genetic, molecular, and biochemical approach. My goal is to understand the functional connections between genes, proteins, metabolites, and mineral ions. I’m also looking at the reduction of iron by a family of membrane-bound Fe(III) reductases and metal metabolism in the symbiosis between Bradyrhizobium japonicum and soybeans.

Curriculum Vitae
HB 6044
Biological Sciences
B.S. Cornell University
Ph.D. Dalhousie University

Selected Publications

Huang, X.Y., Deng, F., Yamaji, N., Pinson, S.R., Fujii-Kashino, M., Danku, J., Douglas, A., Guerinot, M.L., Salt, D.E., Ma, J.F. (2016) A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain. Nat Commun. 2016 Jul 8;7:12138. doi: 10.1038/ncomms12138. PMID:27387148

Mary, V., Schnell Ramos, M., Gillet, C., Socha, A.L., Giraudat, J., Agorio, A., Merlot, S., Clairet, C., Kim, S.A., Punshon, T,., Guerinot, M.L., Thomine, S.  (2015) Bypassing Iron Storage in Endodermal Vacuoles Rescues the Iron Mobilization Defect in the natural resistance associated-macrophage protein3natural resistance associated-macrophage protein4 Double Mutant. Plant Physiol. 2015 Sep;169(1):748-59. doi: 10.1104/pp.15.00380. Epub Jul 31. PMID: 26232490

Stanton, B.A., Caldwell, K., Congdon, C.B., Disney, J., Donahue, M., Ferguson, E., Flemings, E., Golden, M., Guerinot, M.L., Highman, J., James, K., Kim, C., Lantz, R.C., Marvinney, R.G., Mayer, G., Miller, D., Navas-Acien, A., Nordstrom, D.K., Postema, S., Rardin, L., Rosen, B., SenGupta, A., Shaw, J., Stanton, E., Susca, P. (2015) MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic. Curr Environ Health Rep. Sep;2(3):329-37. doi: 10.1007/s40572-015-0057-9. PMID: 26231509

Zhai, Z., Gayomba, S.R., Jung, H.I., Vimalakumari, N.K., Piñeros, M., Craft, E., Rutzke, M.A., Danku, J., Lahner, B., Punshon, T., Guerinot, M.L., Salt, D.E., Kochian, L.V., Vatamaniuk, O.K. (2014) OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis. Plant Cell. May 27;26(5):2249-2264. PMID: 24867923

Socha, A. and M.L. Guerinot. (2014)  Mn-euvering manganese: the role of transporter gene family members in manganese uptake and mobilization in plants.  Front. Plant Sci. 5:106. doi: 10.3389/fpls.2014.00106

Norton, G.J., Douglas, A., Lahner, B., Yakubova, E., Guerinot, M.L., Pinson, S.R., Tarpley, L., Eizenga, G.C., McGrath, S.P., Zhao, F.J., Islam, M.R., Islam, S., Duan, G., Zhu, Y., Salt, D.E., Meharg, A.A., Price, A.H. (2014) Genome wide association mapping of grain arsenic, copper, molybdenum and zinc in rice (Oryza sativa L.) grown at four international field sites. PLoS One. Feb 25;9(2):e89685. doi: 10.1371/journal.pone.0089685. eCollection. PMID: 24586963

Hong, S., S.A. Kim, M.L. Guerinot and C.R. McClung.  2013.  Reciprocal interaction of the circadian clock with the Fe homeostasis network in Arabidopsis thaliana.  Plant Physiol. 163: 893-903. PMCID: PMC3561027

Schroeder, J.I., E. Delhaize, W.B. Frommer, M.L. Guerinot, M.J. Harrison, L. Herrera-Estrella, T. Horie, L.V. Kochian, R. Munns, N.K. Nishizawa, Y.-F. Tsay and D. Sanders.  2013.  Using membrane transporters to improve crops for sustainable food production.  Nature 497: 60-66.

Hosmani, P.S., T. Kamiya, J. Danku S. Naseer, N. Geldner, M.L. Guerinot and D.E. Salt.  2013.   A dirigent-domain containing protein is part of the machinery required for formation of the lignin-based Casparian strip in the root.  Proc. Natl. Acad. Sci. U.S.A.  110:14498-503

Zhang, M, S.R.M. Pinson, L. Tarpley, X. Huang, B. Lahner, E. Yakubova, M.L. Guerinot, and D.E. Salt.  2013.  Mapping and validation of quantitative trait loci associated with concentrations of 16 elements in unmilled rice grain.  Theor. Appl. Genet.  10.1007/s00122-013-2207-5

Palmer, C., M.N. Hindt, H. Schmidt, S. Clemens and M.L. Guerinot.  2013.  MYB10 and MYB72 Are required for growth under iron-limiting conditions.  PLoS Genet.  9(11):e1003953

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