Michael B. Hoppa
Assistant Professor of Biological SciencesAssistant Professor in the Molecular and Cellular Biology Graduate Program
The focus of this lab is to understand the molecular basis of electrical excitability in the brain. We combine cutting-edge optical approaches with genetic, molecular and biochemical approaches to study cellular physiology and ion channel trafficking in neurons. The goal of this research is to provide novel insights into a number of areas: identifying molecular modulators of ion channel function, novel forms of neural plasticity, and the roots of hyperexcitability in diseases such as epilepsy.
Ariel, P., Hoppa, M.B., Ryan, T.A. (2012) Intrinsic variability in Pv, RRP size, Ca(2+) channel repertoire, and presynaptic potentiation in individual synaptic boutons. Front Synaptic Neurosci. 2012;4:9.
Hoppa, M.B., Lana, B., Margas, W., Dolphin, A.C., Ryan, T.A. (2012) α2δ expression sets presynaptic calcium channel abundance and release probability. Nature. May 13;486(7401):122-5.
Hoppa, M.B., Jones, E., Karanauskaite, J., Ramracheya, R., Braun, M., Collins, S.C., Zhang, Q., Clark, A., Eliasson, L., Genoud, C., Macdonald, P.E., Monteith, A.G., Barg, S., Galvanovskis, J., Rorsman, P. (2012) Multivesicular exocytosis in rat pancreatic beta cells. Diabetologia. Apr;55(4):1001-12. doi: 10.1007/s00125-011-2400-5
Collins, S.C., Hoppa, M.B., Walker, J.N., Amisten, S., Abdulkhader, F., Bengtsson, M., Fearnside, J., Ramracheya, R., Toye, A.A., Zhang, Q., Clark, A., Gauguier, D., Rorsman, P. (2010) Progression of diet-induced diabetes in C57Bl6J mice involves functional dissociation of Ca2+ channels from secretory vesicles. Diabetes. May;59(5):1192-201.
Hoppa, M.B., Collins, S., Ramracheya, R., Hodson, L., Amisten, S., Zhang, Q., Johnson, P., Ashcroft, F.M., Rorsman, P. (2009) Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. Cell Metabolism. Dec;10(6):455-65.