Nicholas J. Jacobs
Professor Emeritus of Microbiology and ImmunologyAdjunct Professor Emeritus of Biological Sciences
Much of my research has been in the area of bacterial pathogenesis as well as clinical and public health microbiology. Special focus has been on diagnosis and antimicrobial therapy of infections in compromised hosts, such as patients with cystic fibrosis, AIDS, and cancer. Additional research areas include the biochemical and toxicological aspects of heme and chlorophyll biosynthesis in humans, bacteria, and plants.
Morales DK, Grahl N, Okegbe C, Dietrich LE, Jacobs NJ, Hogan DA
Control of Candida albicans metabolism and biofilm formation by Pseudomonas aeruginosa phenazines.
MBio 2013 Jan 29; 4(1):e00526-12
Morales DK, Jacobs NJ, Rajamani S, Krishnamurthy M, Cubillos-Ruiz JR, Hogan DA
Antifungal mechanisms by which a novel Pseudomonas aeruginosa phenazine toxin kills Candida albicans in biofilms.
Mol Microbiol 2010 Dec; 78(6):1379-92
Measurement of protoporphyrinogen oxidase activity. Jacobs JM, Jacobs NJ. Curr Protoc Toxicol. (2001). May;Chapter 8:Unit 8
Polyclonal Mycobacterium avium infections in patients with AIDS: variations in antimicrobial susceptibilities of different strains of M. avium isolated from the same patient. von Reyn CF, Jacobs NJ, Arbeit RD, Maslow JN, Niemczyk S. J Clin Microbiol. (1995). Apr;33(4):1008-10.
Terminal enzymes of heme biosynthesis in the plant plasma membrane. Jacobs JM, Jacobs NJ. Arch Biochem Biophys. (1995) Nov 10;323(2):274-8.
Inhibitory effect of disodium EDTA upon the growth of Staphylococcus epidermidis in vitro: relation to infection prophylaxis of Hickman catheters. Root JL, McIntyre OR, Jacobs NJ, Daghlian CP Antimicrob Agents Chemother. (1988) Nov; 32(11):1627-31
Protoporphyrinogen oxidation, a step in heme synthesis in soybean root nodules and free-living rhizobia. Jacobs NJ, Borotz SE, Guerinot ML. (1989) J Bacteriol. Jan; 171(1):573-6
Protoporphyrinogen oxidation, an enzymatic step in heme and chlorophyll synthesis: partial characterization of the reaction in plant organelles and comparison with mammalian and bacterial systems. Jacobs JM, Jacobs NJ. Arch Biochem Biophys. (1984) Feb 15;229(1):312-9
Characterization and incidence of pigment production by human clinical group B streptococci. Merritt K, Jacobs NJ. (1978) J Clin Microbiol. Jul;8(1): 105-7
Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda. Gorman N, Zaharia A, Trask HS, Szakacs JG, Jacobs NJ, Jacobs JM, Balestra D, Sinclair JF, Sinclair PR. Hepatology (2007). Jan; 45(1):187-94