Roger D. Sloboda
Ira Allen Eastman Professor of Biological SciencesProfessor in the Molecular and Cellular Biology Program
Cilia and flagella, which project from the cell surface of many different cell types, are involved in cell motility. They also act like antenna and sense environmental conditions. They are taken apart at each cell division and reassembled by the two, newly formed daughter cells. Our lab is studying the steps required for the disassembly of cilia and flagella to occur prior to the start of cell division.
Werner-Petersen, R and RD Sloboda. "Methylation of Structural Components of the Axoneme Occurs During Flagellar Disassembly," Biochemistry,(2013) 52:8501-09.
Schneider, M J, M Ulland, and R D Sloboda, “A Protein Methylation Pathway in Chlamydomonas Flagella Is Active during Flagellar Resorption,” Molecular Biology of the Cell , 19 (2008) 4319-4327.
Sloboda, R D, and J L Rosenbaum, “Making Sense of Cilia and Flagella,” Journal of Cell Biology , 179:4 (2007) 575-582. http://www.jcb.org/cgi/content/full/179/4/575
Sloboda, R D, and L Howard, “Localization of EB1, IFT Polypeptides, and Kinesin-2 in Chlamydomonas Flagellar Axonemes via Immunogold Scanning Electron Microscopy,” Cell Motility and the Cytoskeleton , 64:6 (2007) 446-460. http://www3.interscience.wiley.com/cgi-bin/fulltext/114130035/PDFSTART
Kitareewan, S, B D Roebuck, E Demidenko, R D Sloboda, and E Dmitrovsky, “Lysosomes and Trivalent Arsenic Treatment in Acute Promyelocytic Leukemia,” Journal of the National Cancer Institute , 99:1 (2007) 41-52. http://jnci.oxfordjournals.org/cgi/content/abstract/99/1/41
“Intraflagellar Transport and the Flagellar Tip Complex,” Journal of Cellular Biochemistry , 94:2 (2005) 266-272. http://www3.interscience.wiley.com/cgi-bin/fulltext/109752348/HTMLSTART??
Pedersen, L B, S Geimer, R D Sloboda, and J L Rosenbaum, “The Microtubule Plus End-tracking Protein EB1 is localized to the Flagellar Tip and Basal Bodies in Chlamydomonas reinhardtii ,” Current Biology , 13 (2003) 1969-1974. http://www.current-biology.com/content/article/abstract?uid=PIIS09609822...