Bing He

Academic Appointments
  • Assistant Professor of Biological Sciences

  • Molecular and Cellular Biology Graduate Program

  • Cancer Biology and Developmental Therapeutics Research Program, Norris Cotton Cancer Center

I am interested in how complex tissue and organ structures arise from simple tissue primordia. Tissue morphogenesis is not only controlled biochemically but also an intrinsically mechanical process. Using an interdisciplinary approach combining genetics, cell biology, biophysics and mathematical modeling, I seek to understand how developmental patterning information controls individual cell shape changes and how they are integrated into stereotyped tissue-scale deformations.

Contact

350 Life Sciences Center
HB 6044

Education

  • B.S. Peking University
  • Ph. D. University of Pennsylvania

Selected Publications

  • Bing He*, Adam Martin, Eric Wieschaus. (2016) Flow-dependent myosin recruitment during Drosophila cellularization requires zygotic dunk activity. Development 143(13):2417-30. * Corresponding author.

    https://www.ncbi.nlm.nih.gov/pubmed/27226317

  • Bing He, Konstantin Doubrovinski, Oleg Polyakov, Eric Wieschaus (2014) Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation. Nature 508(7496):392-6.

    https://www.ncbi.nlm.nih.gov/pubmed/24590071

  • Oleg Polyakov, Bing He, Michael Swan, Joshua Shaevitz, Matthias Kaschube, Eric Wieschaus (2014). Passive mechanical forces control cell shape change during Drosophila ventral furrow formation. Biophysical Journal 107(4):998-1010.

    https://www.ncbi.nlm.nih.gov/pubmed/25140436

  • Bing He, Amy Caudy, Lance Parsons, Adam Rosebrock, Attilio Pane, Sandeep
    Raj, Eric Wieschaus
    (2012) Mapping the pericentric heterochromatin by comparative genomic hybridization analysis and chromosome deletions in Drosophila melanogaster. Genome Research 22(12):2507-19.

    https://www.ncbi.nlm.nih.gov/pubmed/22745230

+ View more