Carey D. Nadell
Associate Professor
Appointments
Associate Professor of Biological Sciences
Adjunct Associate Professor of Microbiology and Immunology
Adjunct Associate Professor of Orthopaedic Surgery
MCB Graduate Program
Area of Expertise
microbial ecology/ population biology / social evolution / biofilms
Biography
Bacteria often live in groups, called biofilms, where they cooperate and compete with each other using a broad spectrum of interactive behaviors. These interactions are central to how bacteria evolve, and how they impact the world around them. We use tools from ecology, evolution, microscopy, and molecular biology to understand the cell-scale mechanisms and biofilm-scale consequences of bacterial social interaction.
Education
B.A. University of Oxford
M.A. Princeton University
Ph. D. Princeton University
Publications
Robitaille, S., Simmons, E.L., Verster, A.J., McClure, E.A., Royce, D.B., Swartz, K., Schultz, D., Nadell, C.D., Ross, B.D. (2023). Community composition and the environment modulate the population dynamics of Type IV secretion in human gut bacteria. (2023). Nature Ecology and Evolution (in press)
Smith, W.P.J., Wucher, B.R., Nadell, C,D., Foster, K.R. (2023). Bacterial defences: mechanisms, evolution, and antimicrobial resistance. Nature Reviews Microbiology 21: 519-534
Wucher, B.R., Winans, J.B., Elsayed, M., Kadouri, D.E., Nadell, C.D†. (2023). Breakdown of clonal cooperative architecture in multispecies biofilms and the spatial ecology of predation. PNAS 120(6): e2212650120.
Winans, J.B., Wucher, B.R., Nadell, C.D†. (2022). Multispecies biofilm architecture determines bacterial exposure to phages. PLoS Biology: e3001913
Huber, M., Lippegaus, A., Melamed, S., Siemers, M., Wucher, B.R.*, Nadell, C.D., Storz, G., Papenfort, K. (2022). An RNA sponge controlling quorum sensing dynamics and biofilm formation in Vibrio cholerae. Nature Communications13: 7585
Teschler, J.K., Jiménez-Siebert, E., Jeckel, H., Singh, P.K., Park, J.H., Pukatzki, S., Nadell, C.D., Drescher. K., Yildiz, F.H. (2022) VxrB Influences Antagonism within Biofilms by Controlling Competition through Extracellular Matrix Production and Type 6 Secretion. mBio. Jul 26:e0188522. doi: 10.1128/mbio.01885-22. Online ahead of print. PMID: 35880882
Tai, J.B., Mukherjee, S., Nero, T., Olson, R., Tithof, J., Nadell, C.D., Yan, J. (2022) Social evolution of shared biofilm matrix components. Proc Natl Acad Sci U S A. Jul 5;119(27):e2123469119. doi: 10.1073/pnas.2123469119. Epub 2022 Jun 30. PMID: 35771939
Teschler, J.K., Nadell, C.D., Drescher, K., Yildiz, F.H. (2022) Mechanisms Underlying Vibrio cholerae Biofilm Formation and Dispersion. Annu Rev Microbiol. 2022 Jun 7. doi: 10.1146/annurev-micro-111021-053553. Online ahead of print. PMID: 35671532
Kerkaert, J.D., Le Mauff, F., Wucher, B.R., Beattie, S.R., Vesely, E.M., Sheppard, D.C., Nadell, C.D., Cramer, R.A. (2022) An Alanine Aminotransferase Is Required for Biofilm-Specific Resistance of Aspergillus fumigatus to Echinocandin Treatment. mBio. Apr 26;13(2):e0293321. doi: 10.1128/mbio.02933-21. Epub 2022 Mar 7. PMID: 35254131
Kasetty, S., Katharios-Lanwermeyer, S., O'Toole, G.A., Nadell, C.D. (2021) Differential Surface Competition and Biofilm Invasion Strategies of Pseudomonas aeruginosa PA14 and PAO1. J Bacteriol. 2021 Oct 25;203(22):e0026521. doi: 10.1128/JB.00265-21. Epub 2021 Sep 13. PMID: 34516283
Koeppen, K., Nymon, A., Barnaby, R., Bashor, L., Li, Z., Hampton, T.H., Liefeld, A.E., Kolling, F.W., LaCroix, I.S., Gerber, S.A., Hogan, D.A., Kasetty, S., Nadell, C.D., Stanton, B.A. (2021) Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2105370118. doi: 10.1073/pnas.2105370118. PMID: 34260396
Bond. M.C., Vidakovic, L., Singh, P.K., Drescher, K., Nadell, C.D. (2021) Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells. Elife. Jul 9;10:e65355. doi: 10.7554/eLife.65355. PMID: 34240700
Kasetty, S., Mould, D.L., Hogan, D.A., Nadell, C.D. (2021) Both Pseudomonas aeruginosa and Candida albicans Accumulate Greater Biomass in Dual-Species Biofilms under Flow. mSphere. Jun 30;6(3):e0041621. doi: 10.1128/mSphere.00416-21. Epub 2021 Jun 23. PMID: 34160236
Wucher BR, Elsayed M, Adelman JS, Kadouri DE, Nadell CD† (2021). Bacterial predation transforms the landscape and community assembly of biofilms. Current Biology 31: 1-9
Bond MC, Vidakovic L, Singh PK, Drescher K, Nadell CD†. (2021). Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells. eLife 10:e65355
Kasetty D, Mould DL, Hogan DA, Nadell CD†. (2021). Both Pseudomonas aeruginosa and Candida albicans accumulate greater biomass in dual-species biofilm under flow. mSphere 6(3): e00416-21
Kowalski CH, Morelli KA, Stajich JE, Nadell CD, Cramer RA (2021). A heterogeneously expressed gene family modulates the biofilm architecture and hypoxic growth of Aspergillus fumigatus. mBio 12(1): e03579-20
Koeppen K, Nymon A, Barnaby R, Bashor L, Li Z, Hampton TH, Liefield AE, Kolling FW, LaCroix IS, Gerber S, Hogan DA, Kasetty K, Nadell CD, Stanton BA. (2021). Let-7b-5c in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic susceptibility of P. aeruginosa. Proceedings of the National Academy of Sciences USA 118(28): e2105370118
Kowalski CH, Morelli KA, Schultz D, Nadell CD, Cramer RA. (2020) Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance. Proceedings of the National Academy of Sciences USA. Sep 8;117(36):22473-22483
Simmons EL, Bond MC, Koskella B, Drescher K, Bucci V, Nadell CD. (2020) Biofilm Structure Promotes Coexistence of Phage-Resistant and Phage-Susceptible Bacteria. mSystems. Jun 23;5(3):e00877
Díaz-Pascual F, Hartmann R, Lempp M, Vidakovic L, Song B, Jeckel H, Thormann KM, Yildiz FH, Dunkel J, Link H, Nadell CD, Drescher K. (2019) Breakdown of Vibrio cholerae biofilm architecture induced by antibiotics disrupts community barrier function. Nature Microbiology. Dec;4(12):2136-2145
Kitts G, Giglio KM, Zamorano-Sánchez D, Park JH, Townsley L, Cooley RB, Wucher BR, Klose KE, Nadell CD, Yildiz FH, Sondermann H. (2019) A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae. mBio. Dec 3;10(6):e02822-19
Wucher BW, Bartlett TM, Persat A, Nadell CD (2019). Vibrio cholerae filamentation promotes chitin surface attachment at the expense of competition in biofilms. Proceedings of the National Academy of Sciences USA 116(28): 14216-14221
Rossy T, Nadell CD, Persat A. (2018). Cellular advection-diffusion drives emergence of bacterial surface colonization patterns and heterogeneity. Nature Communications 10(1): 2471
Martinez-Garcia R, Nadell CD, Hartmann R, Drescher K, Bonachela J† (2018). Cell adhesion and fluid flow jointly initiate genotype spatial distribution in biofilms. PLoS Computational Biology 14(4): e1006094
Vidakovic L, Singh PK, Hartmann R, Nadell CD, Drescher K. (2018). Dynamic biofilm architecture confers individual and collective mechanisms of viral protection. Nature Microbiology 3: 26-31
Simmons M, Drescher K, Nadell CD, Bucci V. (2017). Phage mobility is a core determinant of phage–bacteria coexistence in biofilms. ISME Journal 12: 531-543
Singh PK, Hartmann R, Bartolomej S, Nadell CD, Drescher K. (2017). Vibrio cholerae combines individual and collective sensing to trigger biofilm dispersal. Current Biology 27: 1-8
Yan J, Nadell CD, Stone HA, Wingreen NS, Bassler BL (2017). Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion. Nature Communications 8: 327
Nadell CD, Ricaurte D*, Yan J, Drescher K, Bassler B (2017). Flow environment and matrix structure interact to shape spatial competition in P. aeruginosa biofilms. eLife 6: e21855
Nadell CD, Hartmann R, Drescher K. (2016) An emerging grip on the growth of grounded bacteria. ACS Nano 10:9109-9110 (commentary)
Nadell CD, Drescher K, Foster KR. (2016) Spatial structure, cooperation, and competition in biofilms. Nature Reviews Microbiology 14: 589-600
Drescher K, Dunkel J, Nadell CD, van Teeffelen S, Grnja I, Wingreen NS, Stone HA, Bassler BL. (2016) Architectural transitions in Vibrio cholerae biofilm development at single-cell resolution. Proceedings of the National Academy of Sciences USA 113(4): E2066-2072
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