Carey Davis Nadell

Assistant Professor
Academic Appointments

Assistant Professor of Biological Sciences
Graduate Program in Ecology, Evolution, Ecosystems and Society
Molecular and Cellular Biology Graduate Program

Bacteria often live in groups, called biofilms, where they cooperate and compete with each other using a broad spectrum of interactive behaviors. These interactions are central to how bacteria evolve, and how they impact the world around them. We use tools from ecology, evolution, microscopy, and molecular biology to understand the cell-scale mechanisms and biofilm-scale consequences of bacterial social interaction.

Personal Website
Class of 1978 Life Sciences Center, room 326
HB 6044
Department:
Biological Sciences
Education:
B.A. University of Oxford
M.A. Princeton University
Ph. D. Princeton University

Selected Publications

Wucher BW, Bartlett TM, Persat A, Nadell CD† (2018). Vibrio cholerae filamentation promotes chitin surface attachment at the expense of competition in biofilms. Proceedings of the National Academy of Sciences USA 116(28): 14216-14221

Simmons M*, Bond MC*, Drescher K, Bucci V, Nadell CD† (2019). Evolutionary dynamics of phage resistance in bacterial biofilms. bioRxiv 552265 (in review)

Kowalski CH, Kerkaert JD, Nadell CD, Stajich J, Cramer RA (2019). Architecture of in vitro fungal morphotypes distates lesion morphology and disease progression through a novel collagen-like protein. (In press, Nature Microbiology)

Diaz-Pascual F, Hartmann R, Lempp M, Vidakovic L, Song B, Yildiz F, Dunkel J, Link H, Nadell CD, Drescher K (2019). Breakdown of biofilm architecture in response to antibiotics facilitates community invasion. (In revision, Nature Microbiology)

Rossy T, Nadell CD†, Persat A† (2018). Cellular advection-diffusion drives emergence of bacterial surface colonization patterns and heterogeneity. Nature Communications 10(1): 2471

Martinez-Garcia R, Nadell CD†, Hartmann R, Drescher K, Bonachela J† (2018). Cell adhesion and fluid flow jointly initiate genotype spatial distribution in biofilms. PLoS Computational Biology 14(4): e1006094

Simmons M, Drescher K, Nadell CD†, Bucci V† (2018). Phage mobility is a core determinant of phage-bacteria coexistence in biofilms. ISME Journal 12: 531-543

Vidakovic L, Singh PK, Hartmann R, Nadell CD†, Drescher K† (2018). Dynamic biofilm architecture confers individual and collective mechanisms of viral protection. Nature Microbiology 3: 26-31

Singh PK, Hartmann R, Bartolomej S, Nadell CD, Drescher K (2017). Vibrio cholerae combines individual and collective sensing to trigger biofilm dispersal. Current Biology 27: 1-8

Yan J, Nadell CD, Stone HA, Wingreen NS, Bassler BL (2017). Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion. Nature Communications 8: 327

Nadell CD*, Ricaurte D*, Yan J, Drescher K, Bassler B (2017). Flow environment and matrix structure interact to shape spatial competition in P. aeruginosa biofilms. eLife 6: e21855

Phage mobility is a core determinant of phage-bacteria coexistence in biofilms.  Simmons M, Drescher K, Nadell CD†, Bucci V† (2017). ISME Journal :12(2): 531–543.

Dynamic biofilm architecture confers individual and collective mechanisms of viral protection. Vidakovic L, Singh PK, Hartmann R, Nadell CD†, Drescher K† (2017). Nature Microbiology (2017) doi: 10.1038/s41564-017-0050-1   (†corresponding)

Vibrio cholerae combines individual and collective sensing to trigger biofilm dispersal. Singh PK, Hartmann R, Bartolomej S, Nadell CD, Drescher K. (2017). Current Biology 27:1-8

Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion. Yan J, Nadell CD, Stone HA, Wingreen NS, Bassler BL. (2017). Nature Communications 8:327

Flow environment and matrix structure interact to shape spatial competition in P. aeruginosa biofilms. Nadell CD*, Ricaurte D*, Yan J, Drescher K, Bassler B (2017).  eLife 6: e21855    (*co-first authors)

An emerging grip on the growth of grounded bacteria. Nadell CD, Hartmann R, Drescher K (2016). ACS Nano 10:9109-9110   (commentary)

Spatial structure, cooperation, and competition in biofilms. Nadell CD†, Drescher K, Foster KR†. (2016). Nature Reviews Microbiology 14: 589-600   (†corresponding)

Architectural transitions in Vibrio cholerae biofilm development at single-cell resolution. Drescher K, Dunkel J, Nadell CD, van Teeffelen S, Grnja I, Wingreen NS, Stone HA, Bassler BL. (2016). Proceedings of the National Academy of Sciences USA 113(4): E2066-2072

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