Mary Lou Guerinot

Professor

Appointments

Professor of Biological Sciences

Ronald and Deborah Harris Professor in the Sciences

Professor in the Molecular and Cellular Biology Graduate Program

Professor in the Microbiology and Molecular Pathogenesis Program

Member of the National Academy of Sciences

Fellow of the American Association for the Advancement of Science

Fellow of the American Society of Plant Biologists

Salk Institute Non-Resident Fellow

Area of Expertise

Iron homeostasis,

metal uptake and transport,

mineral nutrition,

metal regulation of gene expression,

plant-microbe interactions

Biography

I am a molecular geneticist whose principal expertise and research interests are in the area of metal transport and regulation of gene expression by metals.  For most of the world, plants are the major point of entry for metals into the food chain, so work in our lab is laying the foundation for crops that offer sustainable solutions for malnutrition and for decreasing exposure to toxic metals.

Education

B.S. Cornell University

Ph.D. Dalhousie University

Publications

Ricachenevsky ,F.K., Campos, A.C.A.L., Menguer, P.K., Betin, F.M.M., Tovar, J., van Dijk, W.F.A., Guerinot, M.L., Salt, D.E., Kover, P.X.  (2025)  Comparison of linkage and association mapping in MAGIC lines identifies ATMTP3 as a new gene controlling natural variation in leaf zinc concentration in Arabidopsis. J. Ext Bot. doi: 10.1093/jxb/eraf142.

Webster, S.S. and M.L. Guerinot. (2024) How plants iron out the competing interests of growth and defence.  Nature 625:671-672. doi: 10.1038/d41586-023-03995-3.

Liu, H., Lu, C., Liu, X-Q., Zhuo, C-J., Luo, R-J., Zhao, C., Pinson, S.R.M., Guerinot, M.L., Salt, D.E., Zhao, F-J., Huang, X-Y. (2024)  A chloroplast localized heavy metal-associated domain containing protein regulates grain calcium accumulation in rice.  Nature Commun.  15:9265

Smieska, L., Guerinot, M.L., Olson Hoal, K., Reid, M., Vatamaniuk, O. (2023) Synchrotron science for sustainability: life cycle of metals in the environment. Metallomics. Aug 1;15(8):mfad041. doi: 10.1093/mtomcs/mfad041. PMID: 37370221

Lee, S., Lee, J., Ricachenevsky, F.K., Punshon, T., Tappero, R., Salt, D.E., Guerinot, M.L. (2021) Redundant roles of four ZIP family members in zinc homeostasis and seed development in Arabidopsis thaliana. Plant J.  Nov;108(4):1162-1173. doi: 10.1111/tpj.15506. Epub 2021 Oct 8. PMID: 34559918

Akmakjian, G.Z., Riaz, N., Guerinot, M.L. (2021) Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3. Proc Natl Acad Sci U S A. Oct 5;118(40):e2024918118. doi: 10.1073/pnas.2024918118. PMID: 34580211

Xu L, Dong Z, Chiniquy D, Pierroz G, Deng S, Gao C, Diamond S, Simmons T, Wipf HM, Caddell D, Varoquaux N, Madera MA, Hutmacher R, Deutschbauer A, Dahlberg JA, Guerinot ML, Purdom E, Banfield JF, Taylor JW, Lemaux PG, Coleman-Derr D. (2021) Genome-resolved metagenomics reveals role of iron metabolism in drought-induced rhizosphere microbiome dynamics. Nat Commun. May 28;12(1):3209. doi: 10.1038/s41467-021-23553-7. PMID: 34050180

Ricachenevsky,  F.K., Punshon, T., Salt, D.E., Fett, J.P., Guerinot, M.L. (2021) Arabidopsis thaliana zinc accumulation in leaf trichomes is correlated with zinc concentration in leaves. Sci Rep. Mar 5;11(1):5278. doi: 10.1038/s41598-021-84508-y. PMID: 33674630

Liu, H., Long, S.X., Pinson, S.R.M., Tang, Z., Guerinot, M.L., Salt, D.E., Zhao, F.J., Huang, X.Y. (2021) Univariate and Multivariate QTL Analyses Reveal Covariance Among Mineral Elements in the Rice Ionome. Front Genet. Jan 25;12:638555. doi: 10.3389/fgene.2021.638555. eCollection 2021. PMID: 33569081

Riaz, N., Guerinot, M.L. (2021) All Together Now: Regulation of the Iron Deficiency Response. J Exp Bot. Jan 15:erab003. doi: 10.1093/jxb/erab003. Online ahead of print. PMID: 33449088 

Ruang-Areerate, P., Travis, A.J., Pinson, S.R.M., Tarpley, L., Eizenga, G.C., Guerinot, M.L., Salt, D.E., Douglas, A., Price, A.H., Norton, G.J. (2020) Genome-wide association mapping for grain manganese in rice (Oryza sativa L.) using a multi-experiment approach. Heredity (Edinb). Nov 24. doi: 10.1038/s41437-020-00390-w. PMID: 33235293 

Mu, S., Yamaji, N., Sasaki, A., Luo, L., Du, B., Che, J., Shi, H., Zhao, H., Huang, S., Deng, F., Shen, Z., Guerinot, M.L., Zheng, L., Ma, J.F. (2020) A transporter for delivering zinc to the developing tiller bud and panicle in rice.  Plant J. Nov 9. doi: 10.1111/tpj.15073. PMID: 33169459 

Fischer, S., Sánchez-Bermejo, E., Xu, X., Flis, P., Ramakrishna, P., Guerinot, M.L., Zhao, F.J., Salt, D.E. (2020) Targeted expression of the arsenate reductase HAC1 identifies cell-type specificity of arsenic metabolism and transport in plant roots. J Exp Bot. Oct 10;72(2):415-25. doi: 10.1093/jxb/eraa465.  PMID: 33038235

Kim, S.A., LaCroix, I.S., Gerber, S.A., Guerinot, M.L. (2019) The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI.  Proc Natl Acad Sci U S A. Dec 10;116(50):24933-24942. doi: 10.1073/pnas.1916892116. . PMID: 31776249

Huang, X.Y., Liu, H., Zhu, Y.F., Pinson, S.R.M., Lin, H.X., Guerinot, M.L., Zhao, F.J., Salt, D.E. (2019) Natural variation in a molybdate transporter controls grain molybdenum concentration in rice. New Phytol. Oct 19. doi: 10.1111/nph.15546. PMID: 30339276

Nachman, K.E., Punshon, T., Rardin, L., Signes-Pastor, A.J., Murray, C.J., Jackson, B.P., Guerinot, M.L., Burke, T.A., Chen, C.Y., Ahsan, H., Argos, M., Cottingham, K.L., Cubadda, F., Ginsberg, G.L., Goodale, B.C., Kurzius-Spencer, M., Meharg, A.A., Miller M.D., Nigra, A.E., Pendergrast, C.B., Raab, A., Reimer, K., Scheckel, K.G., Schwerdtle, T., Taylor, V.F., Tokar, E.J., Warczak, T.M. and Karagas, M.R. (2018) Opportunities and Challenges for Dietary Arsenic Intervention. Environ Health Perspect. Aug;126(8):84503. doi: 10.1289/EHP3997. PMID: 30235424

Ricachenevsky, F.K., Punshon, T., Lee, S., Oliveira, B.H.N., Trenz, T.S., Maraschin, F.D.S., Hindt, M.N., Danku, J., Salt, D.E., Fett, J.P. and Guerinot, M.L. (2018) Elemental Profiling of Rice FOX Lines Leads to Characterization of a New Zn Plasma Membrane Transporter, OsZIP7. Front Plant Sci. Jul 3;9:865. doi: 10.3389/fpls.2018.00865. eCollection 2018. PMID: 30018622

Chu, H.H., Car, S., Socha, A.L., Hindt, M.N., Punshon, T. and Guerinot, M.L. (2017) The Arabidopsis MTP8 transporter determines the localization of manganese and iron in seeds. Sci Rep. Sep 8;7(1):11024. doi: 10.1038/s41598-017-11250-9. PMID: 28887568

Hindt, M.N., Akmakjian, G.Z., Pivarski, K.L., Punshon, T., Baxter, I., Salt, D.E. and Guerinot, M.L. (2017) BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana. Metallomics. 2017 Jul 19;9(7):876-890. doi: 10.1039/c7mt00152e. PMID: 28620661

Punshon, T., Jackson, B.P., Meharg, A.A., Warczak, T., Scheckel, K. and Guerinot, M.L. (2017) Understanding arsenic dynamics in agronomic systems to predict and prevent uptake by crop plants. Sci. Total Environ.  Mar 1;581-582:209-220. doi: 10.1016/j.scitotenv.2016.12.111. Epub 2016 Dec 30. Review. PMID: 28043702

Huang, X.Y., Deng, F., Yamaji, N., Pinson, S.R., Fujii-Kashino, M., Danku, J., Douglas, A., Guerinot, M.L., Salt, D.E., Ma, J.F. (2016) A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain. Nat. Commun. 2016 Jul 8;7:12138. doi: 10.1038/ncomms12138. PMID:27387148

Mary, V., Schnell Ramos, M., Gillet, C., Socha, A.L., Giraudat, J., Agorio, A., Merlot, S., Clairet, C., Kim, S.A., Punshon, T,., Guerinot, M.L., Thomine, S.  (2015) Bypassing Iron Storage in Endodermal Vacuoles Rescues the Iron Mobilization Defect in the natural resistance associated-macrophage protein3natural resistance associated-macrophage protein4 Double Mutant. Plant Physiol. 2015 Sep;169(1):748-59. doi: 10.1104/pp.15.00380. Epub Jul 31. PMID: 26232490

Stanton, B.A., Caldwell, K., Congdon, C.B., Disney, J., Donahue, M., Ferguson, E., Flemings, E., Golden, M., Guerinot, M.L., Highman, J., James, K., Kim, C., Lantz, R.C., Marvinney, R.G., Mayer, G., Miller, D., Navas-Acien, A., Nordstrom, D.K., Postema, S., Rardin, L., Rosen, B., SenGupta, A., Shaw, J., Stanton, E., Susca, P. (2015) MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic. Curr Environ. Health Rep. Sep;2(3):329-37. doi: 10.1007/s40572-015-0057-9. PMID: 26231509

Zhai, Z., Gayomba, S.R., Jung, H.I., Vimalakumari, N.K., Piñeros, M., Craft, E., Rutzke, M.A., Danku, J., Lahner, B., Punshon, T., Guerinot, M.L., Salt, D.E., Kochian, L.V., Vatamaniuk, O.K. (2014) OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis. Plant Cell. May 27;26(5):2249-2264. PMID: 24867923

Socha, A. and M.L. Guerinot. (2014)  Mn-euvering manganese: the role of transporter gene family members in manganese uptake and mobilization in plants.  Front. Plant Sci. 5:106. doi: 10.3389/fpls.2014.00106

Norton, G.J., Douglas, A., Lahner, B., Yakubova, E., Guerinot, M.L., Pinson, S.R., Tarpley, L., Eizenga, G.C., McGrath, S.P., Zhao, F.J., Islam, M.R., Islam, S., Duan, G., Zhu, Y., Salt, D.E., Meharg, A.A., Price, A.H. (2014) Genome wide association mapping of grain arsenic, copper, molybdenum and zinc in rice (Oryza sativa L.) grown at four international field sites. PLoS One. Feb 25;9(2):e89685. doi: 10.1371/journal.pone.0089685. eCollection. PMID: 24586963

Hong, S., S.A. Kim, M.L. Guerinot and C.R. McClung.  2013.  Reciprocal interaction of the circadian clock with the Fe homeostasis network in Arabidopsis thaliana.  Plant Physiol. 163: 893-903. PMCID: PMC3561027

Schroeder, J.I., E. Delhaize, W.B. Frommer, M.L. Guerinot, M.J. Harrison, L. Herrera-Estrella, T. Horie, L.V. Kochian, R. Munns, N.K. Nishizawa, Y.-F. Tsay and D. Sanders.  2013.  Using membrane transporters to improve crops for sustainable food production.  Nature 497: 60-66.

Hosmani, P.S., T. Kamiya, J. Danku S. Naseer, N. Geldner, M.L. Guerinot and D.E. Salt.  2013.   A dirigent-domain containing protein is part of the machinery required for formation of the lignin-based Casparian strip in the root.  Proc. Natl. Acad. Sci. U.S.A.  110:14498-503

Zhang, M, S.R.M. Pinson, L. Tarpley, X. Huang, B. Lahner, E. Yakubova, M.L. Guerinot, and D.E. Salt.  2013.  Mapping and validation of quantitative trait loci associated with concentrations of 16 elements in unmilled rice grain.  Theor. Appl. Genet.  10.1007/s00122-013-2207-5

Palmer, C., M.N. Hindt, H. Schmidt, S. Clemens and M.L. Guerinot.  2013.  MYB10 and MYB72 Are required for growth under iron-limiting conditions.  PLoS Genet.  9(11):e1003953

Contact

Mary.Lou.Guerinot@dartmouth.edu
603-646-2527
Life Sciences Center, Room 325
HB 6044

Departments

Biological Sciences

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