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We study the multicellular interactions between neurons and glia in the brain with a primary focus on the development, plasticity, and regeneration of myelinating oligodendrocytes. Techniques include high-resolution optical imaging in combination with molecular labels, genetic manipulation, and sensors of cellular physiology.
Bame X and Hill RA. Mitochondrial network reorganization and transient expansion during oligodendrocyte generation Nature Communications. (2024) doi: 10.1038/s41467-024-51016-2 PMID: 39143079
Olveda GE, Barasa MN, and Hill RA. Microglial phagocytosis of single dying oligodendrocytes is mediated by CX3CR1 but not MERTK. Cell Reports. (2024) doi: 10.1016/j.celrep.2024.114385 PMID: 38935500
Chapman TW, Kamen Y, Piedra ET, and Hill RA. Oligodendrocyte maturation alters the cell death mechanisms that cause demyelination. The Journal of Neuroscience (2024) doi: 10.1523/JNEUROSCI.1794-23.2024 PMID: 38395617
Chapman TW, Olveda GE, Bame Xh, Pereira E, and Hill RA. Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice. Nature Neuroscience (2023) doi: 10.1038/s41593-023-01271-1 PMID: 36928635, highlighted by Dartmouth News