Sharon E. Bickel

Selected Publications

• Haseeb MA, Weng KA, Bickel SE. 2024. Chromatin-associated cohesin turns over extensively and forms new cohesive linkages in Drosophila oocytes during meiotic prophase. Curr Biol. Jul 8;34(13):2868-2879.e6. doi: 10.1016/j.cub.2024.05.034. Epub 2024 Jun 12. PMID: 38870933

  Haseeb MA, Bernys AC, Dickert EE, Bickel SE. 2024. An RNAi screen to identify proteins required for cohesion rejuvenation during meiotic prophase in Drosophila oocytes.G3 (Bethesda). 2024 Aug 7;14(8):jkae123. doi: 10.1093/g3journal/jkae123. PMID: 38849129

  Haseeb MA, Weng KA, Bickel SE. 2023. Chromatin-associated cohesin turns over extensively and forms new cohesive linkages during meiotic prophase. bioRxiv . 2023 Aug 18:2023.08.17.553729. doi: 10.1101/2023.08.17.553729.

  Perkins AT, Greig MM, Sontakke AA, Peloquin AS, McPeek MA, Bickel SE. 2019. Increased levels of superoxide dismutase suppress meiotic segregation errors in aging oocytes. Chromosoma. 2019 Sep;128(3):215-222. doi: 10.1007/s00412-019-00702-y. Epub 2019 Apr 29. PMID: 31037468

  Perkins, A.T. and Bickel, S.E.. (2017) Using Fluorescence In Situ Hybridization (FISH) to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes .J Vis Exp. Dec 6;(130). doi:10.3791/56802. PMID:29286418         Link to Video

• Perkins, A.T., Das, T.M., Panzera, L.C. and Bickel, S.E.  (2016) Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors.  PNAS: doi: 10.1073/pnas.1612047113.

• Giauque, C.C. and Bickel, SE. (2016)  Heterochromatin-Associated Proteins HP1a and Piwi Collaborate to Maintain the Association of Achiasmate Homologs in Drosophila Oocytes. Genetics.: May;203(1):173-89. doi: 10.1534/genetics.115.186460.

• Weng, K.A., Jeffreys, C.A. and Bickel, S.E. (2014).  Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation.  PLoS Genet.: Sep 11;10(9):

• Subramanian, V.V. and Bickel, S.E. (2009) Heterochromatin-mediated association of achiasmate homologues declines with age when cohesion is compromised. Genetics.: 181:1207-1218.

• Subramanian, V.V. and Bickel, S.E. (2008) Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit Smc1 is reduced. PLoS Genet.: Nov;4(11):e1000263. doi: 10.1371/journal.pgen.1000263.

• Page, S.L., Khetani, R.S.,Lake, C.M., Nielsen, R.J., Jeffress J.K., Bickel, S.E., and Hawley, R.S. (2008) corona is required for higher-order assembly of transverse filaments into full-length synaptonemal complex in Drosophila oocytes . PLoS Genet.: 4(9): e1000194. doi: 10.1371/journal.pgen.1000194.

• Gause, M., Webber, H., Misulovin, Z., Haller, G., Rollins, R.A., Eissenberg, J.C., Bickel, S.E. and Dorsett, D. (2008) Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells. Chromosoma: 17:51-66

• Khetani, R. and Bickel, S.E. (2007) Regulation of cohesion and chromosome core morphogenesis during pachytene in Drosophila oocytes. Journal of Cell Science: 120: 3123-3137.

• Bickel, S E, "Aging (Not So) Gracefully," Nature Genetics: 37 (2005) 1303-1304.

• Webber, H., Howard, L. and Bickel S.E. (2004) The cohesion protein ORD is required for homolog bias during meiotic recombination. Journal of Cell Biology: 164:819-829.

• Balicky, E.M., Young, L., Orr-Weaver, T.L. and Bickel, S.E. (2004) A proposed role for the Polycomb Group protein dRING in meiotic sister-chromatid cohesion. Chromosoma: 112:231-239.

• Jeffreys, C.A, Burrage, P.S, and Bickel, S.E. (2003) A model system for increased meiotic nondisjunction in older oocytes. Current Biology 13:498-503.

• Balicky, E.M., Endres, M.W. Lai, C, and Bickel, S.E. (2002) Meiotic cohesion requires accumulation of ORD on chromosomes prior to condensation. Mol. Biol. Cell: 21:3890-3900.

• Bickel, S.E., Orr-Weaver, T.L. and Balicky, E.M. (2002) The sister-chromatid cohesion protein ORD is required for chiasma maintenance in Drosophila oocytes. Current Biology: 12:925-929.